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Related Experiment Video

Updated: Jun 21, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

[Anti-aging effects by caloric restriction].

Takahiko Shimizu¹, Takuji Shirasawa

¹Research Team for Molecular Biomarkers, Tokyo Metropolitan Institute of Gerontology.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|July 14, 2009

Summary

Caloric restriction (CR) extends lifespan and reduces age-related diseases in animals and humans. This review discusses CR

Area of Science:

Gerontology and metabolic research.
Cellular and molecular biology.

Context:

Caloric restriction (CR) is a dietary regimen shown to extend lifespan and improve healthspan in various organisms.
CR is associated with reduced incidence of age-related diseases and enhanced physiological functions.
Key signaling pathways, including Sirtuin 1 (Sirt1), are implicated in mediating CR's beneficial effects.

Purpose:

To review current research on caloric restriction (CR).
To discuss the anti-aging effects of CR.
To highlight the role of Sirt1 pathway activation in CR's benefits.

Summary:

CR extends lifespan and improves healthspan by modulating key signaling pathways.
Sirt1 deacetylates numerous factors involved in metabolism, stress resistance, and cell growth.

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Solid Plate-based Dietary Restriction in Caenorhabditis elegans

Solid Plate-based Dietary Restriction in Caenorhabditis elegans

Published on: May 28, 2011

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Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

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Published on: April 6, 2022

Solid Plate-based Dietary Restriction in Caenorhabditis elegans

Solid Plate-based Dietary Restriction in Caenorhabditis elegans

Published on: May 28, 2011

Exogenous activators of Sirt1, such as resveratrol, show promise in improving metabolic health.

Impact:

Understanding CR's mechanisms can lead to interventions for age-related diseases.
Sirt1 activation represents a potential therapeutic target for promoting longevity and healthspan.
This research provides insights into optimizing healthspan through dietary and pharmacological strategies.