Related Experiment Video
Updated: Jun 21, 2026
09:54
Laboratory Scale Production and Purification of a Therapeutic Antibody
Published on: January 24, 2017
[Gene therapy for anti-aging medicine]
Hironori Nakagami1, Ryuichi Morishita
1Division of Gene Therapy Science, Graduate School of Medicine, Osaka University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 14, 2009
Summary
Hepatocyte growth factor (HGF) gene therapy shows promise for treating cardiovascular diseases by promoting blood vessel growth and reducing inflammation and cellular aging. This approach could offer new anti-aging strategies for cardiovascular conditions.
Area of Science:
- Gerontology and regenerative medicine
- Cardiovascular research
- Gene therapy applications
Context:
- Aging mechanisms are crucial for understanding age-related diseases.
- Gene therapy has evolved from targeting cancer and congenital diseases to cardiovascular conditions.
- Therapeutic angiogenesis using hepatocyte growth factor (HGF) has shown efficacy and safety in clinical trials for peripheral arterial disease.
Purpose:
- To explore the potential of HGF gene therapy as an anti-aging strategy for cardiovascular diseases.
- To investigate the anti-inflammatory and anti-senescence properties of HGF in the context of cardiovascular health.
Summary:
- Hepatocyte growth factor (HGF) gene therapy, utilizing naked plasmid delivery, was investigated for its angiogenic potential in peripheral arterial diseases.
- Clinical trials demonstrated the efficacy and safety of HGF as an angiogenic factor.
- Emerging evidence indicates HGF possesses anti-inflammatory actions and can attenuate cellular senescence, suggesting broader therapeutic applications.
Impact:
- HGF gene therapy may represent a novel anti-aging therapeutic approach for cardiovascular diseases.
- Understanding HGF's role in senescence and inflammation could lead to new drug discovery for age-related cardiovascular conditions.
- This research broadens the scope of gene therapy applications in managing chronic diseases.
More Related Videos
Related Concept Videos
00:59Gene Therapy
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
00:59Gene Therapy
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
01:31Hybridoma Technology
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
01:26Antibody Actions
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:10Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...