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Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Restorative Care01:19

Restorative Care

Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

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Related Experiment Videos

Vancomycin-resistant enterococci in long-term care facilities.

Shmuel Benenson1, Matan J Cohen, Colin Block

  • 1Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. benenson@hadassah.org.il

Infection Control and Hospital Epidemiology
|July 14, 2009
PubMed
Summary
This summary is machine-generated.

Vancomycin-resistant enterococci (VRE) colonization affects 9.6% of long-term care facility residents. Previous hospitalization and antibiotic use increase VRE rates, while dependency and longer stays decrease them.

Related Experiment Videos

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Healthcare Policy

Background:

  • Vancomycin-resistant enterococci (VRE) pose a significant healthcare challenge.
  • Understanding VRE colonization in long-term care facilities (LTCFs) is crucial for infection control.
  • LTCF residents are a vulnerable population for VRE transmission.

Purpose of the Study:

  • To determine the prevalence of VRE colonization among LTCF residents in Jerusalem.
  • To identify risk factors associated with VRE colonization in this population.
  • To inform improved screening strategies for hospital admissions.

Main Methods:

  • A cross-sectional survey was conducted.
  • 1,215 residents of LTCFs in Jerusalem participated.
  • Data on VRE carriage, previous hospitalizations, antibiotic use, dependency levels, and length of stay were collected.

Main Results:

  • The overall VRE carriage rate was 9.6%.
  • Previous hospitalization and antibiotic treatment were linked to higher VRE colonization rates.
  • Increased resident dependency and prolonged LTCF stays showed a decreased VRE colonization rate.

Conclusions:

  • VRE colonization is prevalent in LTCF residents.
  • Specific factors like prior hospitalization and antibiotic exposure are key risk markers.
  • Findings can guide targeted VRE screening for hospital admissions from LTCFs.