Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"It's Like What Sex Ed Should Probably Be": Fathers' Feedback on a Teen Health Program.

Journal of child and family studies·2026
Same author

Connected Dads, Healthy Teens: A Pilot Study of an Online Father-Teen Program to Support Teens' Sexual Health.

Journal of sex research·2026
Same author

A Digital Program to Promote Sexual Communication Between Early Adolescents and Parents: Development and Acceptability Testing Results.

Journal of sex research·2025
Same author

A Phase 2 Trial of Hydroxychloroquine in Individuals at Risk for Rheumatoid Arthritis.

Arthritis & rheumatology (Hoboken, N.J.)·2025
Same author

The "what" and "how" of father-teen talks about sex and relationships.

Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)·2023
Same author

Parents' perspectives on talk with their adolescent and emerging adult children about sex: A longitudinal analysis.

Sexuality research & social policy : journal of NSRC : SR & SP·2023
Same journal

The young adult with Juvenile Idiopathic Arthritis (JIA): A clinical review of transition, complications, and psychosocial management.

Best practice & research. Clinical rheumatology·2026
Same journal

Impact of fatigue on rheumatic diseases: Current perspectives.

Best practice & research. Clinical rheumatology·2026
Same journal

Pneumocystis prophylaxis in rheumatic disease.

Best practice & research. Clinical rheumatology·2026
Same journal

Cutaneous manifestations in myositis syndromes.

Best practice & research. Clinical rheumatology·2026
Same journal

Systemic sclerosis: A comprehensive systematic review of global epidemiology, sex and ethnic disparities, disease burden, and organ-specific involvement.

Best practice & research. Clinical rheumatology·2026
Same journal

Alopecia across the spectrum of rheumatic disease.

Best practice & research. Clinical rheumatology·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Lupus arthritis.

Jennifer M Grossman1

  • 1Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, UCLA, 1000 Veteran Ave Rm 32-59, Los Angeles, CA 90095, USA. jgrossman@mednet.ucla.edu

Best Practice & Research. Clinical Rheumatology
|July 14, 2009
PubMed
Summary
This summary is machine-generated.

Arthritis is a common manifestation of systemic lupus erythematosus (SLE), often affecting hands and knees. Treatment involves various medications to manage joint pain and inflammation.

More Related Videos

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Related Experiment Videos

Last Updated: Jun 21, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Area of Science:

  • Rheumatology
  • Immunology
  • Orthopedics

Background:

  • Arthritis is a frequent and significant manifestation of systemic lupus erythematosus (SLE).
  • Joints commonly affected include hands and knees, with potential involvement of periarticular structures like tendons.
  • Avascular necrosis (AVN) can also occur, leading to joint pain and disability, particularly in larger joints.

Purpose of the Study:

  • To outline the clinical features of arthritis in patients with SLE.
  • To provide an approach for the differential diagnosis of joint pain in SLE.
  • To discuss current treatment strategies for lupus-associated arthritis.

Main Methods:

  • Review of clinical features associated with SLE arthritis.
  • Discussion of diagnostic considerations for differentiating lupus arthritis from other causes.
  • Summary of therapeutic options for managing arthritis in SLE.

Main Results:

  • Hand and knee joints are most typically affected by SLE-induced arthritis.
  • Inflammation of periarticular structures can lead to tendonitis, tenosynovitis, and tendon rupture.
  • Avascular necrosis (AVN) is a recognized complication causing significant joint pain and disability.

Conclusions:

  • Arthritis in SLE presents with characteristic patterns and potential complications like AVN.
  • Accurate diagnosis is crucial for effective management of SLE-related joint issues.
  • A multi-faceted treatment approach utilizing anti-inflammatories, corticosteroids, anti-malarials, and immunosuppressants is necessary.