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Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Related Experiment Video

Updated: Jun 21, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Weight reduction can decrease circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in

Yasuhiro Nomata1, Noriaki Kume, Hiroyuki Sasai

  • 1Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan. y-nomata@stat.taiiku.tsukuba.ac.jp

Metabolism: Clinical and Experimental
|July 14, 2009
PubMed
Summary

Weight reduction significantly decreased soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in overweight men. This suggests a link between obesity, inflammation, and sLOX-1, a marker associated with cardiovascular disease.

Related Experiment Videos

Last Updated: Jun 21, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Obesity Research

Background:

  • Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) is linked to acute coronary syndrome.
  • The association between sLOX-1 and obesity remains unclear.
  • Investigating sLOX-1 in the context of weight management is crucial for understanding cardiovascular risk.

Purpose of the Study:

  • To determine if a 12-week weight reduction intervention impacts serum sLOX-1 levels in overweight men.
  • To explore correlations between changes in sLOX-1 and various anthropometric and metabolic markers.
  • To identify predictors of sLOX-1 level changes during weight loss.

Main Methods:

  • A 12-week weight reduction intervention was conducted.
  • Thirty-eight overweight middle-aged men participated; 32 completed the study.
  • Serum sLOX-1 levels were measured using chemiluminescent enzyme-linked immunoassay.

Main Results:

  • Significant reductions in body weight (-7.5%) and serum sLOX-1 levels (-72.1%) were observed post-intervention.
  • sLOX-1 changes positively correlated with body weight, BMI, fat mass, total cholesterol, subcutaneous fat, hs-CRP, leptin, and TNF-alpha.
  • Body mass index and high-sensitivity C-reactive protein were significant predictors of sLOX-1 changes.

Conclusions:

  • Weight reduction effectively lowers serum sLOX-1 levels in overweight individuals.
  • LOX-1 induction appears linked to adipocyte metabolism, inflammation, and immune responses associated with obesity.
  • These findings highlight a potential therapeutic target for cardiovascular risk reduction in obesity.