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Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
Published on: June 17, 2013
Proprioception and motor control in Parkinson's disease
Jürgen Konczak1, Daniel M Corcos, Fay Horak
1School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA. jkonczak@umn.edu
Journal of Motor Behavior
|July 14, 2009
Summary
Parkinson's disease (PD) impairs proprioception, the sense of body position. This review highlights how altered proprioception and its integration with motor control contribute to motor deficits and balance issues in PD patients.
Area of Science:
- Neuroscience
- Movement Disorders
- Sensory Neuroscience
Background:
- Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive motor decline.
- PD patients frequently experience sensory deficits, particularly proprioceptive impairments, which significantly worsen motor function.
- Proprioception, the sense of self-movement and body position, is crucial for effective motor control.
Purpose of the Study:
- To review the relationship between proprioception and motor impairments in Parkinson's disease.
- To investigate alterations in kinaesthetic perception sensitivity in PD.
- To explore the role of proprioceptive-motor integration in PD-related motor problems, balance issues, and treatment effects.
Main Methods:
- Literature review focusing on proprioception and motor function in Parkinson's disease.
- Analysis of studies examining kinaesthetic perception sensitivity.
- Synthesis of research on proprioceptive-motor integration, balance, and the impact of levodopa and deep brain stimulation.
Main Results:
- Proprioceptive deficits are prevalent and significantly degrade motor performance in Parkinson's disease.
- Impaired proprioceptive-motor integration is a key factor in the motor symptoms observed in PD.
- Proprioception is closely linked to balance problems in individuals with Parkinson's disease.
Conclusions:
- A failure in processing and integrating proprioceptive information for motor commands is integral to Parkinson's disease motor symptoms.
- Addressing proprioceptive deficits is crucial for understanding and managing motor impairments in PD.
- Further research into proprioception's role can inform therapeutic strategies for Parkinson's disease.
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