Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Basicranial diastematomyelia: a case report.

¹Department of Pathology, Washington University School of Medicine, Barnes Hospital, St, Louis, MO 63110.

Clinical Neuropathology

|September 1, 1991

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-world data in the molecular era-finding the reality in the real world.

Clinical pharmacology and therapeutics·2015

Same author

Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms.

Oncogene·2013

Same author

CRTC1 rearrangements in the absence of t(11;19) in primary cutaneous mucoepidermoid carcinoma.

The British journal of dermatology·2009

Same author

Visceral primitive peripheral neuroectodermal tumors: a clinicopathologic and molecular study.

Human pathology·2001

Same author

Successful in vitro fertilization pregnancy after conservative management of endometrial cancer.

Fertility and sterility·2001

Same author

Primitive neuroectodermal tumors of the biliary and gastrointestinal tracts: clinicopathologic and molecular diagnostic study of two cases.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2001

Diastematomyelia, a spinal cord condition, was observed in the basicranium, suggesting similar developmental origins. This rare congenital anomaly may occur at higher levels than previously documented.

Area of Science:

Developmental biology
Neuroscience
Congenital abnormalities

Background:

Diastematomyelia is a congenital spinal cord malformation characterized by longitudinal division.
It is typically found in the cervical, thoracic, lumbar, and sacral regions.
The underlying cause involves a dividing band of fibrous tissue, cartilage, or bone.

Observation:

This report details a rare case of diastematomyelia involving the basicranium.
The malformation was identified at the base of the skull, a location not previously associated with this condition.

Findings:

The embryologic development of the basicranium and brain supports the proposed mechanisms for diastematomyelia.
These mechanisms, previously linked to spinal cord development, appear to operate at a more cephalad level.

Related Experiment Videos

Implications:

This finding expands the known anatomical distribution of diastematomyelia.
It suggests that the developmental processes leading to diastematomyelia can affect the developing brain and skull base.
Further research into craniovertebral development may elucidate the etiology of this condition.