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Adalimumab-induced autoimmune hepatitis.

Tomer Adar¹, Meir Mizrahi, Orit Pappo

¹Liver Unit, Division of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Journal of Clinical Gastroenterology

|July 14, 2009

Summary

Adalimumab, used for psoriatic arthritis, can cause autoimmune hepatitis. This rare side effect resolved with steroid treatment after adalimumab was stopped.

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Area of Science:

Immunology
Hepatology
Rheumatology

Background:

Antitumor necrosis factor (TNF) antibodies are common treatments for autoimmune diseases.
Adalimumab is a fully human IgG antibody targeting TNF, approved for conditions like psoriatic arthritis.

Observation:

A patient with psoriatic arthritis developed autoimmune hepatitis while undergoing treatment with adalimumab.
This adverse event emerged during adalimumab therapy.

Findings:

The patient recovered fully after adalimumab cessation and initiation of corticosteroid therapy.
This case represents the first documented instance of adalimumab-induced autoimmune hepatitis.

Implications:

Adalimumab therapy may carry a risk of inducing autoimmune hepatitis.
Clinicians should monitor for liver function abnormalities in patients treated with adalimumab.
This finding highlights the complex relationship between TNF inhibition and immune-mediated liver injury.