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Related Experiment Video

Updated: Jun 21, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
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Targeted naltrexone for problem drinkers.

Henry R Kranzler1, Howard Tennen, Stephen Armeli

  • 1Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030-2103, USA. kranzler@psychiatry.uchc.edu

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Targeted naltrexone significantly reduced heavy drinking in men. This approach shows promise for reducing alcohol consumption, especially in male populations.

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Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Psychology

Background:

  • Heavy drinking poses significant health risks.
  • Naltrexone is an opioid antagonist used in addiction treatment.
  • Prior research suggests naltrexone can reduce alcohol consumption.

Purpose of the Study:

  • To replicate and extend research on targeted naltrexone use for reducing heavy drinking.
  • To compare the efficacy of naltrexone versus placebo in individuals aiming to reduce alcohol intake.
  • To investigate the moderating effect of sex on naltrexone's effectiveness.

Main Methods:

  • A 12-week randomized controlled trial involving 163 participants (58.3% male).
  • Participants received either naltrexone (50 mg) or placebo, with instructions for daily or targeted use.
  • An interactive voice response system collected daily self-reports on drinking and medication adherence.
  • Hierarchical linear modeling was used for data analysis, with sex as a moderator.

Main Results:

  • Men in the targeted naltrexone group showed a significant reduction in mean drinks per day at week 12 compared to other groups.
  • The targeted naltrexone group also significantly reduced drinks per drinking day during week 12.
  • Sex did not moderate the effect on drinks per drinking day.

Conclusions:

  • A targeted naltrexone strategy is effective in reducing heavy drinking, particularly among men.
  • While promising, additional strategies or more potent medications may be needed to enhance treatment effects.
  • This study supports targeted medication use as a viable approach for alcohol use disorder interventions.