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Updated: Jun 21, 2026

A Heterotopic Mouse Model for Studying Laryngeal Transplantation
Published on: January 13, 2023
A short perspective on the surgical restoration of alaryngeal speech
Rehan Kazi1, Chris M Nutting, Peter Rhys-Evans
1Head and Neck Unit, Royal Marsden Hospital, London, United Kingdom SW3 6JJ. drrehankazi@gmail.com
Abstract:
Despite advances in conservative laryngeal surgery and radiotherapy, total laryngectomy still remains the procedure of choice for advanced-stage laryngeal carcinoma around the world. The loss of natural voice is very often traumatic for the total laryngectomy patient, presenting lifelong challenges for communication in a world that relies heavily on verbal communication. Functional rehabilitation of these patients has long been one of the major challenges facing clinicians, but it is only in the last three decades that the emphasis on restoration of function and quality of life has become almost as important as cure and survival. Although voice restoration for alaryngeal speakers can be attained with any of 3 speech options - esophageal speech, electrolarynx and surgical voice restoration (SVR) using a valve the SVR technique has today become the preferred method and 'gold standard.' Successful tracheo-esophageal voice restoration in laryngectomy patients can be very rewarding, and patients are no longer condemned to silence while they await the results of their cancer treatments. They can face the challenges of life with the knowledge that a near-normal quality of life is very much possible.
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