Related Experiment Videos
Subunit selective alteration of hepatic glutathione transferases in spontaneously hypertensive rats
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Kobe, Japan.
Abstract:
1. The activities of glutathione (GSH) transferases in male, spontaneously hypertensive rats (SHR) and stroke-prone rats (SHR-SP) were different from those of normotensive male Wistar Kyoto rats (WKY). 2. These alterations of the enzyme activities were partly due to the changes in the levels of subunits 2 and 4. 3. Subunit selective alterations were observed in pathophysiological conditions, namely spontaneous hypertension. 4. The sex-related difference of GSH transferases in these animals was also discussed.