Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Social Risk Factors and Their Effect on Health Care Costs in a Midwestern Health Care System.

Journal of primary care & community health·2026
Same author

Genomic architecture and transcriptional regulation of cellulose degradation in the novel marine bacterium Pseudoxanthomonas sp. JC1303.

Molecular genetics and genomics : MGG·2026
Same author

Seasonal dynamics and assembly mechanisms of Roseobacter clade in Mytilus coruscus aquaculture: Implications for environmental monitoring.

Marine environmental research·2025
Same author

Alterations in bacterial structure and function in seawater due to <i>Mytilus coruscus</i> farming: implications for sustainable aquaculture management.

Frontiers in microbiology·2025
Same author

Relationship between smoking status and ulcerative colitis: a meta-analysis based on a case-control study.

Scientific reports·2025
Same author

Pathogen-derived glyoxylate inhibits Tet2 DNA dioxygenase to facilitate bacterial persister formation.

Cell metabolism·2025
Same journal

N2-substituted triazoles as trypanothione reductase inhibitors: in silico evaluation, synthesis, and anti-leishmanial activity.

Journal of computer-aided molecular design·2026
Same journal

Theoretical study for investigating three experimental dose-response curves of rosy odorants on human olfactory receptor OR2A25 via molecular docking calculations and statistical physics modeling.

Journal of computer-aided molecular design·2026
Same journal

A linear models approach to optimize carbazole-based dyes for solar cell applications.

Journal of computer-aided molecular design·2026
Same journal

DOCKweb: a web-based GUI platform for molecular modeling with DOCK6.

Journal of computer-aided molecular design·2026
Same journal

Two faces of drug repurposing data in machine learning-driven structure-based virtual screening supported by interaction fingerprints.

Journal of computer-aided molecular design·2026
Same journal

Repurposing bleomycin against Acinetobacter baumannii HisG: computational, biophysical, and antibacterial evidence.

Journal of computer-aided molecular design·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

Combinatorial library-based design with Basis Products.

Joe Zhongxiang Zhou1, Shenghua Shi, Jim Na

  • 1Department of Computational and Structural Biology, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA 92121, USA. zjoe.zhou@gmail.com

Journal of Computer-Aided Molecular Design
|July 14, 2009
PubMed
Summary
This summary is machine-generated.

Basis Products (BPs) offer an efficient method for selecting lead compounds from large virtual libraries. This approach significantly reduces computational costs and integrates various drug design strategies.

More Related Videos

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

Related Experiment Videos

Last Updated: Jun 21, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

Area of Science:

  • Medicinal Chemistry
  • Computational Chemistry
  • Drug Discovery

Background:

  • Identifying novel lead compounds from extensive virtual libraries is crucial for pharmaceutical research.
  • Current methods for virtual screening can be computationally intensive and time-consuming.

Purpose of the Study:

  • To introduce and validate Basis Products (BPs) as an efficient selection method for combinatorial libraries.
  • To demonstrate the application of BPs in property-based library design and integration with other drug design paradigms.

Main Methods:

  • Basis Products (BPs) are defined as a strategically selected subset of compounds representing a larger combinatorial library.
  • BP docking scores are utilized to identify top-ranking compounds.
  • The efficiency of BP docking is compared to brute-force docking of entire virtual libraries.

Main Results:

  • Docking with BPs offers substantial computational savings in time and resources compared to brute-force methods.
  • BPs facilitate property-based combinatorial library design.
  • BPs can be integrated with structure-based and fragment-based drug design methods.

Conclusions:

  • Basis Products provide a highly efficient and broadly applicable method for selecting compounds from combinatorial libraries.
  • BPs serve as valuable fragments encoding chemical knowledge, enabling integration of diverse drug design strategies.
  • Potential applications include lead hopping and consensus core building, enhancing drug discovery pipelines.