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Updated: Jun 21, 2026

Isolating LacZ-expressing Cells from Mouse Inner Ear Tissues using Flow Cytometry
11:14

Isolating LacZ-expressing Cells from Mouse Inner Ear Tissues using Flow Cytometry

Published on: December 23, 2011

Hair cell progenitors: identification and regulatory genes

Morgan Bodson1, Ingrid Breuskin, Philippe Lefebvre

  • 1GIGA-Neurosciences, University of Liege, Liege, Belgium.

Acta Oto-Laryngologica
|July 14, 2009
PubMed

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Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of their outer...