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Hemodynamic responses to gram-positive versus gram-negative sepsis in critically ill patients with and without
A J Ahmed1, J A Kruse, M T Haupt
1Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI.
Objective:
To examine the hemodynamic patterns of critically ill patients with septicemia to evaluate their relationship to blood bacteriology.
Design:
Retrospective study.
Setting:
Medical ICUs of a tertiary care medical center.
Patients:
Total of 59 critically ill patients with bacteremia: 33 with Gram-positive and 26 with Gram-negative bacteremia.
Measurements:
Hemodynamic variables and mixed venous oxygen saturation (SvO2) measurements associated with the highest cardiac index measured within 72 hrs of positive blood cultures.
Main Results:
No significant differences in cardiac index, mean arterial pressure, systemic vascular resistance, oxygen extraction ratio, or SvO2 were observed comparing the two groups.
Conclusion:
We were unable to demonstrate clinically important differences between the hemodynamic responses to Gram-positive vs. Gram-negative sepsis.