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Published on: August 10, 2013
Peripheral and central levels in nasal trigeminal sensitization and desensitization
1Laboratoire de Neurosciences, Université de Franche-Comté, Place Leclerc 25000, Besançon, France. gerard.brand@univ-fcomte.fr
Abstract:
In order to investigate the role of central and peripheral mechanisms in nasal trigeminal sensitization/desensitization processes, the present work recorded psychophysical (intensity ratings) and psychophysiological (skin conductance) responses to allyl isothiocyanate volatile nasal stimulation--during normal breathing--in monorhinal condition after a controlateral stimulation of the other nostril. Insofar as both nostrils are anatomically separated, modifications in responses can be interpreted as a central regulation process. Results showed that sensitization was clearly related to central mechanisms contrarily to desensitization which depended only of peripheral level.
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