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Related Experiment Video

Updated: Jun 21, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

[Carbendazim affects testicular development and spermatogenic function in rats].

Gong-chang Yu¹, Lin Xie, Yan-zhong Liu

¹Department of Toxicology, Shandong Academy of Occupational Health and Diseases, Jinan, Shandong 250002, China.

Zhonghua Nan Ke Xue = National Journal of Andrology

|July 15, 2009

Summary

Carbendazim exposure harms male rat testicular development and sperm production. This damage is linked to increased cell death (apoptosis) and altered protein expression (Bcl-2/Bax).

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Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

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Published on: March 6, 2018

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Published on: August 6, 2014

Area of Science:

Reproductive toxicology
Endocrinology
Cell biology

Context:

Carbendazim is a widely used fungicide with known reproductive toxicity.
Understanding its specific effects on male reproductive health is crucial for risk assessment.
Previous studies suggest potential adverse effects, but mechanisms require further elucidation.

Purpose:

To investigate the impact of carbendazim on testicular development and spermatogenesis in male rats.
To elucidate the underlying molecular mechanisms, including apoptosis and Bcl-2/Bax protein expression.

Summary:

Male Wistar rats were exposed to varying doses of carbendazim (20, 100, 200 mg/kg) for 80 days.
Carbendazim exposure led to testicular atrophy, reduced sperm count and motility, and altered histopathology.
Increased apoptosis and altered Bcl-2/Bax expression were observed in a dose-dependent manner.

Impact:

Carbendazim significantly impairs male reproductive function in rats.
The mechanism involves carbendazim-induced apoptosis mediated by the Bcl-2/Bax pathway.
Findings highlight the reproductive risks associated with carbendazim exposure.