Related Experiment Video
Updated: Jun 21, 2026
Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice
Published on: September 19, 2019
[Repair effect of BMSCs on digestive tract injury]
Guiqing Jia1, Mingming Zhang, Xiaoting Wu
1Department of Gastrointestional Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China.
Objective:
To investigate the effect of BMSCs on the repair of digestive tract injury and its mechanisms.
Methods:
Recent literature on the effect of BMSCs on the repair of digestive tract injury was reviewed.
Results:
BMSCs had the potency of self-replication, proliferation and multipotential differentiation, which played an important role in the repair of digestive tract injury. The probable mechanisms included: BMSCs' ability of migrating to the injured tissue and inhibiting the host immune response; BMSCs' dedifferentiation and redifferentiation; BMSCs' direct differentiation into the epithelial cells or the stem cells of digestive tract; BMSCs' fusion with the stem cells or the mature epithelial cells of digestive tract; BMSCs' participation in the reconstruction of injured microenvironment.
Conclusion:
BMSCs participates in the repair of digestive tract injury and has a bright future in the treatment of digestive system disease.
