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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
Published on: March 25, 2014
Immunization with peptide-protein conjugates: impact on benchmarking B-cell epitope prediction for vaccine design
1Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Philippines. badong@post.upm.edu.ph
Abstract:
Benchmarking B-cell epitope prediction for vaccine design is meaningful if based on empirical reference data pertaining to cross-reactivities of antipeptide antibodies with native protein antigens; yet it is complicated by such data acquired using antibodies raised against peptide-protein conjugates, as peptide-protein conjugation can differentially suppress antibody responses to peptide epitopes.
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