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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Medication errors in elderly people: contributing factors and future perspectives.

Daniela Fialová1, Graziano Onder

  • 1Department of Geriatrics and Gerontology, 1 Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. daniela.fialova@faf.cuni.cz

British Journal of Clinical Pharmacology
|July 15, 2009
PubMed
Summary
This summary is machine-generated.

Older adults experience frequent medication errors due to complex health needs and prescribing challenges. Addressing research and practice gaps is crucial for safe medication use in the elderly.

Related Experiment Videos

Area of Science:

  • Geriatric Pharmacology
  • Clinical Pharmacy
  • Medication Safety

Background:

  • Older adults exhibit significant variability in health, disability, and medication needs, complicating prescribing.
  • Inappropriate and erroneous medication use is common in the elderly due to prescribing complexities and patient-specific factors.

Purpose of the Study:

  • To highlight the challenges and factors contributing to medication errors in older adults.
  • To identify gaps in research and clinical practice regarding geriatric medication use.

Main Methods:

  • Review of factors contributing to medication errors in older populations.
  • Analysis of geriatric-specific aspects influencing medication safety.

Main Results:

  • Polypharmacy, polymorbidity, fragmented care, and age-related physiological changes increase medication error risk.
  • Lack of geriatric-specific evidence, underuse of geriatric assessment, and inconsistent recommendations exacerbate the problem.

Conclusions:

  • Gaps in geriatric clinical pharmacology and pharmacy services contribute to medication errors.
  • Future research and regulatory measures are needed to ensure appropriate and errorless medication use in older adults.