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Heart rate variability in beta-thalassemia patients
Wasarut Rutjanaprom1, Natnicha Kanlop, Pimlak Charoenkwan
1Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
European Journal of Haematology
|July 15, 2009
Summary
Heart rate variability (HRV) is reduced in beta-thalassemia major (TM) patients. Improved HRV correlates with higher hemoglobin levels, indicating anemia impacts cardiac autonomic balance.
Area of Science:
- Cardiology
- Hematology
- Autonomic Nervous System Research
Background:
- Cardiac failure is a leading cause of mortality in beta-thalassemia major (TM).
- Reduced heart rate variability (HRV) is linked to increased arrhythmia risk in heart conditions.
- The study investigates HRV in TM patients.
Purpose of the Study:
- To evaluate heart rate variability (HRV) in beta-thalassemia major (TM) patients.
- To assess the relationship between HRV and hemodynamic/echocardiographic parameters.
- To understand the impact of anemia on cardiac autonomic function in TM.
Main Methods:
- Evaluated 34 TM patients and 20 healthy controls.
- Measured hematologic, biochemical, echocardiographic, and HRV parameters over 6 months.
- Analyzed 24-h electrocardiograms for time and frequency domain HRV.
Main Results:
- TM patients exhibited significantly reduced HRV compared to controls.
- Improved HRV correlated positively with higher hemoglobin (Hb) levels within the TM group.
- No correlation found between HRV and serum ferritin, ROS, or NTBI.
Conclusions:
- HRV is depressed in beta-thalassemia major patients.
- Hemoglobin level is a significant factor influencing cardiac autonomic balance in TM.
- Anemia plays a crucial role in cardiac autonomic dysfunction in TM.
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