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Updated: Jun 21, 2026

A BW Reporter System for Studying Receptor-Ligand Interactions
Published on: January 7, 2019
Endogenous ligands for C-type lectin receptors: the true regulators of immune homeostasis
Juan J García-Vallejo1, Yvette van Kooyk
1Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Abstract:
C-type lectin receptors (CLRs) have long been known as pattern-recognition receptors implicated in the recognition of pathogens by the innate immune system. However, evidence is accumulating that many CLRs are also able to recognize endogenous 'self' ligands and that this recognition event often plays an important role in immune homeostasis. In the present review, we focus on the human and mouse CLRs for which endogenous ligands have been described. Special attention is given to the signaling events initiated upon recognition of the self ligand and the regulation of glycosylation as a switch modulating CLR recognition, and therefore, immune homeostasis.
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