Malarial proteins that interact with the erythrocyte membrane and cytoskeleton

Several distinct classes of Plasmodium proteins have been proposed to interact with the submembrane skeleton of the erythrocyte based upon differential solubility and subcellular localization studies. That the parasite affects the erythrocyte membrane by interacting with the submembrane skeleton is an attractive hypothesis since the membrane skeleton likely regulates many aspects of membrane topography and function. The precise interactions between host and parasite proteins at the molecular level and how the parasite proteins are transported to the erythrocyte membrane are not completely understood. Experiments addressing these questions are under way, and such studies will provide valuable information about the host-parasite interface. In addition, the characterization of the interaction of Plasmodium proteins with the host erythrocyte membrane may also provide new insight into the structure and function of the erythrocyte membrane or membranes in general.