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Cerebrovascular disease and dementia: a primate model of hypertension and cognition

Mark B Moss1, Elizabeth Jonak

  • 1Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA. markmoss@bu.edu

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|July 15, 2009
PubMed

Insights

High blood pressure (hypertension) is linked to cognitive decline. This study introduces a rhesus monkey model to investigate how hypertension impacts brain function and cognition, offering new research avenues.

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Aging Research

Background:

  • Epidemiological studies link cardiovascular risk factors like hypertension to cognitive decline and Alzheimer's disease.
  • The precise mechanisms connecting hypertension and cognitive impairment remain largely unknown.
  • Animal models are crucial for understanding these complex relationships.

Purpose of the Study:

  • To introduce and validate a non-human primate model for studying hypertension's effects on cognition.
  • To provide a valuable tool for investigating the link between cardiovascular health and cognitive function.

Main Methods:

  • Development of a rhesus monkey model of hypertension using aorta coarctation.
  • Utilizing non-human primates, which offer cognitive functions closer to humans compared to rodents.

Main Results:

  • Successfully established a rhesus monkey aorta coarctation model of hypertension.
  • This model is proposed as a valuable tool for cognitive research in hypertension.

Conclusions:

  • Non-human primate models, specifically this aorta coarctation model, are well-suited for studying the impact of hypertension on cognition.
  • This model holds significant potential for advancing research into cardiovascular disease and its neurological consequences.

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