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Related Concept Videos

Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...

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Related Experiment Video

Updated: Jun 21, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Do we know enough to begin prevention interventions for dementia?

Peter V Rabins1

  • 1Johns Hopkins School of Medicine, Baltimore, MD, USA. pvrabins@jhmi.edu

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|July 15, 2009
PubMed
Summary

Successful prevention interventions exist, and evidence links vascular disease risk factors like hypertension to dementia. This supports a proactive campaign to prevent cognitive decline in later life.

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Last Updated: Jun 21, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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Published on: January 11, 2020

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Area of Science:

  • Gerontology
  • Neurology
  • Public Health

Background:

  • Cognitive decline and dementia are significant public health concerns in aging populations.
  • Existing prevention strategies have shown success in various health domains.
  • Understanding risk factors for dementia is crucial for developing targeted interventions.

Purpose of the Study:

  • To review successful prevention interventions.
  • To assess the availability of data supporting a prevention campaign for cognitive decline and dementia.
  • To evaluate the link between vascular disease risk factors and dementia incidence.

Main Methods:

  • Literature review of successful prevention interventions.
  • Analysis of data supporting dementia prevention campaigns.
  • Examination of evidence linking vascular disease risk factors to dementia.

Main Results:

  • Prior prevention interventions demonstrate feasibility and success.
  • Data are available to support a campaign targeting late-life cognitive decline.
  • Strong evidence links hypertension, hyperlipidemia, and diabetes mellitus to increased dementia risk.

Conclusions:

  • A prevention campaign targeting cognitive decline and dementia is warranted.
  • Interventions addressing vascular risk factors can potentially reduce dementia incidence.
  • Public health initiatives should focus on managing vascular health to promote brain health in aging individuals.