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Updated: Jun 21, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
[Resolution of chiral molecules of pharmaceutical interest by means of preferential crystallization]
1Unité de Croissance Cristalline et de Modélisation Moléculaire, Université de Rouen, 76821 Mont Saint-Aignan cedex, France. gerard.coquerel@univ-rouen.fr
Summary:
Various aspects of the chiral discrimination in the solid state are examined. The interests of the conglomerate are illustrated by two applications: the preparative enantiomeric purification and the preferential crystallization. The latter process is described by a careful examination of the heterogeneous equilibria that govern the crystallization and its selectivity. Two variants of the preferential crystallization are detailed. A "good" example illustrates the productivity at the laboratory scale. The ratio between homochiral interaction energies and heterochiral interaction energies at different (hkl) interfaces are involved in the "difficult" cases where the entrainment effect is limited.
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