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Updated: Jun 21, 2026

High-throughput Antiviral Assays to Screen for Inhibitors of Zika Virus Replication
Published on: October 30, 2021
Potent aza-peptide derived inhibitors of HCV NS3 protease
Srikanth Venkatraman1, Wanli Wu, Neng-Yang Shih
1Schering Plough Research Institute, K15-MS 3545, Kenilworth, NJ 07033, United States. Srikanth.Venkatraman@spcorp.com
Abstract:
Chronic hepatitis C infection is the primary cause for cirrhosis of the liver and hepatocellular carcinoma leading to liver failure and transplantation. The etiological agent hepatitis C virus produces a single positive strand RNA that is processed further with the help of NS3 serine protease to produce mature virus. Inhibition of this protease can potentially be used to develop drugs for HCV infections. Boceprevir is a ketoamide derived novel inhibitor of HCV NS3 protease that has been progressed to clinical trials and proven to be efficacious in humans. Herein, we report our efforts in identifying an aza-peptide derivative as a potential second generation compound, that lacks electrophilic ketoamide group and are potent in enzyme and replicon assay.
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