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Updated: May 10, 2026

Detection of DNA Breaks in Dividing Human Cells by Neutral Comet Assay
Published on: August 23, 2024
Breaking up just got easier to do
Hannah L Klein1, Lorraine S Symington
1Department of Biochemistry, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, USA. hannah.klein@nyumc.org
Abstract:
The SLX4 protein functions as a platform for catalytic subunits of structure-specific endonucleases. Findings reported in Cell (Fekairi et al., 2009; Svendsen et al., 2009) and in Molecular Cell (Andersen et al., 2009; Muñoz et al., 2009) now identify the human SLX4 and show that in association with the SLX1 endonuclease it directs the symmetric cleavage and resolution of Holliday junctions.
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