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MYC gene amplification in double minute chromosomes in an aggressive large B-cell lymphoma with leukemic
F Alseraye1, R Padmore, M Wozniak
1Division of Hematopathology and Transfusion Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada. falseraye@ottawahospital.on.ca
Cancer Genetics and Cytogenetics
|July 15, 2009
Abstract:
Double-minute chromosomes (dmin) are small chromatin particles that lack a centromere. They represent extrachromosomal form of gene amplification. Dmin are very rarely encountered in lymphoid neoplasms. We describe a case of a leukemic presentation of large B-cell lymphoma with dmin. Fluorescence in situ hybridization analysis identified these dmin as comprising MYC genes.

