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Developing a Rat Model for Bipolar Disorder

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Bipolar disorder as a risk factor for repeat DUI behavior.

Mark J Albanese¹, Sarah E Nelson, Allyson J Peller

¹Harvard Medical School, Cambridge Health Alliance, Somerville, MA 02143, United States. malbanese@challiance.org

Journal of Affective Disorders

|July 15, 2009

Summary

This summary is machine-generated.

Bipolar disorder (BD) and substance use disorders (SUD) are common in repeat DUI offenders. Many BD patients with SUD have other mental health conditions and low treatment engagement, indicating a need for better screening and care in DUI programs.

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Area of Science:

Psychiatry
Addiction Medicine
Forensic Psychology

Background:

Bipolar disorder (BD) is more common in individuals with substance use disorders (SUD) than the general population.
Recidivist driving under the influence (DUI) offenders exhibit high rates of SUD and elevated BD prevalence.
Previous studies indicate high comorbidity and low treatment engagement in BD patients with SUD.

Purpose of the Study:

To investigate the prevalence of other mental disorders.
To assess treatment engagement and status among DUI offenders with BD and SUD.

Main Methods:

A cohort of 729 repeat DUI offenders in an inpatient treatment program was assessed.
The Composite International Diagnostic Interview (CIDI) was used to generate DSM-IV diagnoses.

Main Results:

BD was linked to higher lifetime prevalence of alcohol, drug, and other psychiatric disorders, including PTSD.
About 25% of BD participants had not discussed mania with a professional.
Only 50% of BD participants reported effective mania treatment, with fewer receiving recent treatment.

Conclusions:

The study cohort was primarily Caucasian males in a Massachusetts DUI program, often attending as a sentencing option.
Clinicians in DUI settings should screen for BD and initiate treatment.
Findings highlight the need for integrated mental health and substance abuse treatment in forensic populations.