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Updated: Jun 21, 2026

Assay Development for High-Throughput Drug Screening Against Mycobacteria
Published on: October 25, 2024
Antimalarial activity of tigecycline, a novel glycylcycline antibiotic
P Starzengruber1, K Thriemer, R Haque
1Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
Abstract:
Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidence interval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.
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