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DYRK2 expression may be a predictive marker for chemotherapy in non-small cell lung cancer
Shin-ichi Yamashita1, Masao Chujo, Toshihiko Moroga
1Department of Surgery II, Faculty of Medicine, Oita University, Yufu, Oita 879-5593, Japan. yamashi1@med.oita-u.ac.jp
Background:
The possibility of a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase gene, DYRK2, predicting benefit from chemotherapy for patients with recurrent non-small cell lung cancer (NSCLC) was investigated.
Materials And Methods:
Forty patients with recurrent disease after surgery received several combinations of platinum-based chemotherapy. The chemotherapy effectiveness was evaluated according to RECIST (response evaluation criteria in solid tumors). Immunohistochemical (IHC) analysis was used to determine the expression of DYRK2.
Results:
Although the response rates between the two groups did not show statistical differences, the disease control rate of the DYRK2-positive group (15 out of 17, 88%) was significantly different from the DYRK2-negative group (8 out of 23, 35%, p=0.001). The median time to the progression (TTP) of disease was significantly different between the two groups (310 days in the positive group, 120 days in the negative, HR=2.12, 95% CI=[1.1-4.09], p=0.024). Multivariate analysis showed that negative DYRK2 expression was a strong predictor of disease progression (HR=3.01, 95% CI=[1.45-6.26], p=0.003).
Conclusion:
Patients with high DYRK2 expression could be good candidates for chemotherapy.
