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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Human papillomavirus, genital warts, and vaccines
1Divisions of Clinical Microbiology and Infectious Diseases, Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. hsporen@ntu.edu.tw
Abstract:
Human papillomavirus (HPV)-related diseases, including cancers, low-grade neoplasia, genital warts, and recurrent respiratory papillomatosis, have a substantial impact on public health. The increasing incidence of HPV infection and genital warts highlights the need for an effective strategy for the management of this disease. Immunization holds the promise of reducing the overall burden of clinical HPV-related diseases. A prophylactic quadrivalent HPV 6/11/16/18 vaccine is highly effective for reducing the risk of HPV 6-, 11-, 16-, and 18-associated cervical cancer, precancerous cervical lesions, and external genital lesions, including genital warts.
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