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MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
Tremor in Klinefelter's syndrome improved by testosterone administration
Journal of Neurology
|July 15, 2009
Summary
Tremor in Klinefelter's syndrome (KS) may differ from essential tremor. Testosterone therapy reduced tremor amplitude and improved handwriting in one KS patient, suggesting a unique pathogenesis.
Area of Science:
- Neurology
- Genetics
- Endocrinology
Background:
- Essential tremor is often presumed in patients with Klinefelter's syndrome (KS).
- Previous research suggested potential differences in tremor characteristics between KS and essential tremor.
- Understanding these differences is crucial for accurate diagnosis and effective treatment.
Observation:
- A 71-year-old male with KS presented with postural hand tremor.
- Electromyography revealed lower motor neuron disturbance and chronic neurogenic changes.
- Muscle biopsy showed neurogenic muscle atrophy.
Findings:
- The patient's tremor differed from typical essential tremor.
- Testosterone administration led to a reduction in tremor amplitude.
- Handwriting gradually improved following testosterone treatment.
Implications:
- This case supports the hypothesis that tremor in KS may have a distinct pathogenesis.
- Testosterone therapy shows promise for managing tremor in Klinefelter's syndrome.
- Further research into KS-associated tremor is warranted to refine treatment strategies.
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