Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces

Related Experiment Video

Updated: Jun 21, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Mark Y Chan1, Jeffrey I Weitz, Yahye Merhi

  • 1National University Heart Centre, Singapore, Singapore. chanyymark@gmail.com

Journal of Thrombosis and Thrombolysis
|July 15, 2009
PubMed

Insights

Catheter thrombosis during percutaneous coronary intervention (PCI) is poorly understood, impacting antithrombotic therapy development. Further research is needed to clarify its causes and clinical impact.

Area of Science:

  • Cardiovascular Medicine
  • Biomaterials Science
  • Hematology

Background:

  • Catheter thrombosis is a complication of percutaneous coronary intervention (PCI).
  • Its incidence, etiology, and pathophysiology are not well understood, leading to underreporting in clinical trials.
  • Factors like catheter materials, device size, procedural characteristics, and antithrombotic drugs influence thrombosis risk.

Purpose of the Study:

  • To review the physiological basis of catheter and guidewire thrombosis in PCI.
  • To explore the effects of antithrombotic drugs on blood-material interactions.
  • To propose a classification for diagnosing and investigating catheter thrombosis in clinical trials.

Main Methods:

  • Literature review focusing on the prothrombotic environment of PCI.
  • Analysis of factors influencing catheter thrombosis (materials, device properties, procedural elements, drugs).
  • Exploration of cellular interactions (platelets, tissue factor) at the blood-material interface.

Main Results:

  • Catheter thrombosis is influenced by a complex interplay of device, procedural, and pharmacologic factors.
  • Cellular interactions, particularly involving platelets and tissue factor, are critical.
  • Existing antithrombotic therapies' effects at the blood-material interface require further investigation.

Conclusions:

  • Understanding catheter thrombosis is crucial for developing effective antithrombotic therapies in PCI.
  • A standardized classification system is proposed for better diagnosis and research in clinical trials.
  • Further research is needed to elucidate the mechanisms and optimize management of catheter thrombosis.

More Related Videos

In Vitro Thrombosis Test for Ventricular Assist Devices09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting08:53

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...