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Updated: Sep 3, 2026
A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
Published on: November 11, 2022
Correlation of collagen-linked fluorescence and tendon fiber breaking time
R Rolandi1, A Borgoglio, P Odetti
1Department of Physics, University of Genova, Italy.
Abstract:
We review in this paper some reported data on age-dependent modification of proteins pointing out the relationship between the increase of nonenzymatic glycation in abdominal skin collagen of Wistar rats, evaluated by fluorescence intensity, and tendon breaking time, used as a parameter of collagen stiffness. Fluorescence intensity data linearly correlate with the breaking times of collagen fibers from Wistar rats reported from different sources, according to the hypothesis of a common etiological mechanism. It is possible to suppose that posttranslational modifications of proteins play a role in the tissue aging and their level in collagen may be used as a parameter for quantitation.
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