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Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life

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Updated: Jun 21, 2026

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
10:21

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

Translational research and biomedical informatics.

Michael Liebman1

  • 1Strategic Medicine, Inc., Kennett Square, PA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|July 15, 2009
PubMed
Summary
This summary is machine-generated.

Biomedical Informatics addresses clinical decision-making challenges by integrating technology and data. This field drives patient care evolution in the post-genome era.

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Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
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Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

Working with Human Tissues for Translational Cancer Research
07:48

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Published on: November 26, 2015

Area of Science:

  • Biomedical Informatics
  • Clinical Decision Support
  • Health Technology

Background:

  • Physicians face complex clinical decisions impacting patient outcomes and quality of life.
  • A gap exists between clinical needs and available technological solutions.
  • The post-genome era presents new opportunities and challenges in healthcare.

Purpose of the Study:

  • To highlight the role of Biomedical Informatics in bridging the gap between clinical needs and technological advancements.
  • To emphasize the potential of Biomedical Informatics in enhancing patient care.
  • To discuss the integration of clinical data and clinician input for improved decision-making.

Main Methods:

  • Literature review on current clinical decision-making processes.
  • Analysis of technological integration in healthcare settings.
  • Exploration of data-driven approaches in patient care.

Main Results:

  • Biomedical Informatics serves as a crucial bridge between clinical practice and technological innovation.
  • Integration of clinical data and clinician expertise enhances decision-making accuracy.
  • Biomedical Informatics facilitates the evolution of patient care models.

Conclusions:

  • Biomedical Informatics is essential for optimizing clinical decisions and patient outcomes.
  • Leveraging technology and data is key to advancing healthcare in the post-genome era.
  • Interdisciplinary collaboration is vital for successful implementation of biomedical informatics solutions.