Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined Obstetric and Thrombotic Complications Are Associated with Features Suggestive of an Immune-Enriched Phenotype Among Women with Thrombotic Antiphospholipid Syndrome (APS).

Diagnostics (Basel, Switzerland)·2026
Same author

Giant Retroperitoneal Liposarcoma.

The American journal of medicine·2026
Same author

Low factor XI activity in heart failure: A potential marker of disease severity?

Kardiologia polska·2026
Same author

Correcting CFTR mRNA splicing defects with the plant cytokine kinetin and its analogues.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2025
Same author

Factor XI Deficiency in apoE/FXI Double-Knockout Mice Decreases Atherosclerosis by Lowering <i>MSR1</i> mRNA Expression Within the Plaque.

Journal of lipid and atherosclerosis·2025
Same author

Identification of phenotypes in thrombotic primary antiphospholipid syndrome using cluster analysis: a step toward personalized medicine.

Journal of thrombosis and haemostasis : JTH·2025
Same journal

Bridging the Gap in Laboratory Monitoring of Extended Half-Life Factor VIII and IX: Can Thrombin Generation Assays Overcome Assay Discrepancies?

Seminars in thrombosis and hemostasis·2026
Same journal

External Quality Assessment for Low Molecular Weight Heparin Monitoring in the Australasia/Asia-Pacific Region.

Seminars in thrombosis and hemostasis·2026
Same journal

Human evolution: between hemorrhage and thrombosis.

Seminars in thrombosis and hemostasis·2026
Same journal

Full- vs Reduced-Dose Direct Oral Anticoagulants for Extended Treatment of Cancer-Associated Thrombosis: A Multicenter Retrospective Cohort Study.

Seminars in thrombosis and hemostasis·2026
Same journal

Too Old for PESI?: Risk Stratification of Octogenarians with Pulmonary Embolism in the Emergency Department.

Seminars in thrombosis and hemostasis·2026
Same journal

Acute Management and Bleeding Outcomes in Pediatric Pulmonary Embolism: A Large Single-Center Retrospective Cohort Study.

Seminars in thrombosis and hemostasis·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice
06:08

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice

Published on: January 7, 2019

Factor XI Deficiency.

Stefano Duga1, Ophira Salomon

  • 1Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy.

Seminars in Thrombosis and Hemostasis
|July 15, 2009
PubMed
Summary
This summary is machine-generated.

Severe factor XI (FXI) deficiency, a bleeding disorder prevalent in Ashkenazi Jews, presents new insights into its clinical features, genetic links, and treatment challenges. Understanding FXI deficiency aids in managing this rare bleeding condition.

More Related Videos

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
07:20

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Related Experiment Videos

Last Updated: Jun 21, 2026

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice
06:08

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice

Published on: January 7, 2019

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
07:20

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Area of Science:

  • Hematology
  • Genetics
  • Molecular Biology

Background:

  • Severe factor XI (FXI) deficiency is an inherited bleeding disorder.
  • It is disproportionately common in the Ashkenazi Jewish population.
  • Over 180 mutations in the FXI gene have been identified, with five exhibiting a founder effect.

Purpose of the Study:

  • To present novel findings on the clinical presentation of FXI deficiency.
  • To explore genotype-phenotype correlations in patients with FXI deficiency.
  • To discuss challenges encountered in treating FXI deficiency.

Main Methods:

  • Review of clinical data from patients with FXI deficiency.
  • Analysis of genetic mutations within the FXI gene.
  • Evaluation of treatment outcomes and challenges.

Main Results:

  • Identification of specific FXI mutations with founder effects, particularly in Ashkenazi Jews.
  • Observation of inhibitor development in patients with null allele mutations.
  • Promising results with low-dose recombinant activated factor VII treatment.
  • Reported survival advantages in patients with severe FXI deficiency.

Conclusions:

  • FXI deficiency exhibits diverse clinical presentations and genotype-phenotype correlations.
  • Treatment strategies, including recombinant activated factor VII, show potential.
  • Further research is needed to address treatment complexities and improve patient outcomes.