Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraventricular hemorrhage as clinical presentation of herpes simplex virus encephalitis. A case report and review of the literature.

The International journal of neuroscience·2020
Same author

Effects of di(2-etilhexil) phthalate on human umbilical artery.

Chemosphere·2019
Same author

Diabetes in the hospitalized patients with urological diseases.

Journal of medicine and life·2015
Same author

Genetic linkage mapping in peach using morphological, RFLP and RAPD markers.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Frequency and mechanism of ischemic stroke associated with malignancy: a retrospective series.

European neurology·2012
Same author

Permanent Genetic Resources added to Molecular Ecology Resources Database 1 December 2009-31 January 2010.

Molecular ecology resources·2011

Related Experiment Video

Updated: Jun 21, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
10:31

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

Published on: September 26, 2025

[Lipoprotein-associated phospholipase A(2) and stroke].

F J Alvarez-Pérez1, I Verde

  • 1Departamento de Medicina, Facultad de Ciencias de la Salud, Universidad de Beira Interior, Hospital de Covilhã, Covilhã, Portugal. franciscoplus@hotmail.com

Revista De Neurologia
|July 15, 2009
PubMed
Summary

High levels of Lipoprotein-associated phospholipase A2 (Lp-PLA2) indicate increased vascular event risk. Further research is needed to define Lp-PLA2

Area of Science:

  • Biochemistry
  • Enzymology
  • Cardiovascular Research

Context:

  • Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme primarily bound to LDL-cholesterol.
  • Lp-PLA2 hydrolyzes oxidized phospholipids in LDL, generating pro-inflammatory products within atheroma plaques.
  • Elevated Lp-PLA2 levels are positively correlated with LDL-cholesterol and associated with increased vascular risk.

Purpose:

  • To review existing data on the relationship between Lp-PLA2 levels and stroke risk.
  • To synthesize findings from cohort and case-control studies examining Lp-PLA2 and cardiovascular events.
  • To evaluate the independent role of Lp-PLA2 as a cardiovascular risk factor.

Summary:

  • Higher Lp-PLA2 levels are associated with an increased risk of first cardiovascular events, including ischemic stroke, and recurrent events.

More Related Videos

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Related Experiment Videos

Last Updated: Jun 21, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
10:31

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

Published on: September 26, 2025

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

  • Lp-PLA2 is an independent risk factor for cardiovascular events, irrespective of traditional risk factors, non-HDL cholesterol, and C-reactive protein.
  • The enzyme's role in plaque destabilization supports the development of Lp-PLA2 inhibitor drugs.

    • Impact:

    • Patients with high Lp-PLA2 levels may be at greater risk for vascular events.
    • Further definition of Lp-PLA2's pathophysiological role in stroke is necessary.
    • Ongoing Phase II clinical trials in coronary heart disease will provide further insights into Lp-PLA2 inhibition.