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The human cardiac troponin I locus: assignment to chromosome 19p13.2-19q13.2
C MacGeoch1, P J Barton, W J Vallins
1Imperial Cancer Research Fund, Clare Hall Laboratories, Potters Bar, Herts, UK.
Human Genetics
|November 1, 1991
Abstract:
The three major troponin I isoforms are encoded by separate genes and are expressed in a muscle-type-specific manner. A human cardiac troponin I cDNA has recently been isolated and used to establish the genomic location of the cardiac troponin I gene locus (designated TNNC1). By somatic cell hybrid analysis, the locus for TNNC1 maps to human chromosome 19 and can be localised to the region p13.2-q13.2.