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Related Experiment Videos

Rat interscapular brown adipose tissue at different ages: a morphometric study.

A Sbarbati1, M Morroni, C Zancanaro

  • 1Istituto di Anatomia Umana ed Istologia, Università di Verona, Italy.

International Journal of Obesity
|September 1, 1991
PubMed
Summary
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Interscapular brown adipose tissue (IBAT) in rats grows until 26 weeks. Contrary to previous beliefs, the number of multilocular adipocytes in adult IBAT remains stable, suggesting no significant involution.

Area of Science:

  • Physiology
  • Histology
  • Adipose Tissue Biology

Background:

  • Interscapular brown adipose tissue (IBAT) plays a crucial role in thermogenesis.
  • Previous studies suggested an involution phase of IBAT after early extrauterine life.

Purpose of the Study:

  • To define morphological modifications of IBAT in rats across different age groups.
  • To assess the validity of involution phase statements in IBAT.

Main Methods:

  • Morphometric analysis of serial IBAT sections from rats aged newborn to 104 weeks.
  • Quantification of multilocular, monolocular, and connective-vascular components.

Main Results:

  • IBAT weight and volume increased progressively up to 26 weeks, then stabilized.

Related Experiment Videos

  • The volume of unilocular and connective components increased with age.
  • Multilocular adipocyte volume peaked at 6 months and slightly decreased, but cell numbers remained constant from 3 weeks to 2 years.

    • Conclusions:

    • IBAT undergoes significant growth and morphological changes during the first 26 weeks of life in rats.
    • The number of multilocular adipocytes in adult rat IBAT is not reduced compared to younger animals, challenging the notion of a significant involution phase.