Changes of rabbit platelet function on simultaneous administration of ticlopidine hydrochloride and OKY-046

Ticlopidine hydrochloride 180 mg was given orally to rabbits and OKY-046 50 mg was simultaneously administered intravenously. Ticlopidine inhibited the platelet aggregation induced by ADP when the Ticlopidine was orally administered separately, but the platelet aggregation induced by PAF, collagen and arachidonic acid (A.a.) was not significantly decreased. Simultaneous administration of Ticlopidine and OKY-046, as compared to administration of Ticlopidine alone, led to a significant decrease in the platelet aggregation induced by A.a. and collagen. The simultaneous administration did not give rise to an additive or synergistic effect on the platelet aggregation induced by ADP.