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The human placenta in diabetes mellitus.

Y Z Diamant¹

¹Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel.

Israel Journal of Medical Sciences

|August 1, 1991

Summary

Pregnancy with diabetes alters placental hormones and blood supply, causing structural and biochemical changes. This review updates knowledge on placental tissue characteristics and their link to function.

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Area of Science:

Obstetrics and Gynecology
Endocrinology
Perinatal Medicine

Background:

Diabetes in pregnancy disrupts the hormonal and metabolic environment.
Altered maternal and fetal blood supply impacts placental development.
These disruptions can lead to placental structural and biochemical changes.

Purpose of the Study:

To review current information on placental tissue.
To correlate structural, biochemical, and immunological characteristics with placental function.
To update knowledge on diabetes' effects during pregnancy.

Main Methods:

Literature review of scientific articles.
Analysis of structural placental alterations.
Evaluation of biochemical markers in placental tissue.
Assessment of immunological factors in the placenta.

Main Results:

Diabetes in pregnancy is linked to significant placental structural and biochemical modifications.
Functional and metabolic disturbances in the placenta are associated with these changes.
Immunological characteristics of the placenta are also affected.

Conclusions:

Placental tissue undergoes profound changes in pregnancies complicated by diabetes.
Understanding these structural and biochemical alterations is crucial for assessing placental function.
Further research is needed to fully elucidate the immunological aspects and their functional implications.

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