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Renal dysfunction in enteric fever.

S N Khosla1, R Lochan

  • 1Department of Medicine, Medical College and Hospital, Rohtak, Haryana.

The Journal of the Association of Physicians of India
|May 1, 1991
PubMed
Summary
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Enteric fever can cause temporary kidney problems in some patients. These renal dysfunctions are usually short-lived and fully reversible, with no lasting damage observed in this study.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Enteric fever, a systemic infection caused by Salmonella Typhi, can affect multiple organs.
  • Kidney involvement in enteric fever is not well-characterized, necessitating further investigation into its impact on renal function.

Purpose of the Study:

  • To evaluate the effects of enteric fever on various kidney functions.
  • To assess the reversibility and clinical significance of renal dysfunction in enteric fever patients.

Main Methods:

  • Studied 25 culture-positive enteric fever cases and 15 controls with non-specific fever.
  • Assessed renal function through urine analysis, blood urea, serum creatinine, electrolytes, 24-hour urine studies, creatinine clearance, imaging (X-ray, IVU), and immune complex levels.

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Main Results:

  • Four patients (16%) exhibited renal dysfunction.
  • Abnormalities in renal function were significant but transient and reversible upon repeat testing.
  • Renal biopsies in three affected patients showed no significant abnormalities.

Conclusions:

  • Enteric fever can lead to reversible renal dysfunction.
  • The observed renal abnormalities are typically short-lasting and do not result in permanent kidney damage.