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ADAM28 as a target for human cancers

Satsuki Mochizuki1, Yasunori Okada

  • 1Department of Pathology, School of Medicine, Keio University, Tokyo, Japan. smochi@sc.itc.keio.ac.jp

Current Pharmaceutical Design
|July 16, 2009
PubMed

Insights

ADAM28, a metalloproteinase, is overexpressed in lung and breast cancers, correlating with proliferation and metastasis. Its activity and gene expression are discussed as potential cancer therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • ADAM28 belongs to the ADAM (a disintegrin and metalloproteinase) gene family, with two known isoforms.
  • It possesses a metalloproteinase domain with catalytic activity and a disintegrin domain that interacts with specific integrins.

Purpose of the Study:

  • To review data on proADAM28 activation and tissue localization in human cancers.
  • To discuss ADAM28's regulation, functions in cancer, and potential as a therapeutic target.

Main Methods:

  • Review of existing data on ADAM28.
  • Analysis of ADAM28 expression and function in human cancers.

Main Results:

  • ADAM28 is overexpressed in human non-small cell lung and breast carcinomas.
  • Expression correlates with increased carcinoma cell proliferation and lymph node metastasis.

Conclusions:

  • ADAM28 plays a significant role in human cancer progression.
  • ADAM28 represents a potential therapeutic target for various cancers.

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