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Updated: Jun 21, 2026

Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy
Published on: January 18, 2018
Cyclin dependent kinases as attractive targets to prevent transcription from viral genomes
Fatah Kashanchi1, Kylene Kehn-Hall
1The George Washington University, Department of Microbiology, Immunology, and Tropical Medicine, 2300 I Street, NW, Washington, DC 20037, USA.
Abstract:
Most viral treatments target the virus itself, providing very specific effects and limiting side-effects on uninfected cells. However, this strategy of drug design often results in resistant viruses, especially among RNA viruses. Therefore, the focus has turned to drugs that target cellular proteins that are essential for viral replication, but not for cellular viability. Pharmacological CDK inhibitors are a prime example of this type of approach. Reviewed within are the various functions of CDKs, their role in the life cycle of selected Retroviruses and Herpesviruses, and the pharmacological CDK inhibitors that have been focused on in terms of viral inhibition.
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