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The use of tripeptides for lead discovery of 5-HT4 receptor ligands
A Hanna-Elias1, P E Thompson, D T Manallack
1Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Vic. 3052, Australia.
Protein and Peptide Letters
|July 16, 2009
Abstract:
A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further synthetic work.
