PRP with subcorneal acantholysis: case report and review
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Updated: Jun 21, 2026
Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
Published on: November 22, 2024
Anita Sebastian1, Amy Beth Koff, Lynne J Goldberg
1Department of Pathology, Drexel College of Medicine, Philadelphia, PA 19130, USA. anita_sebastian@yahoo.com
Abstract:
Although the clinical findings of pityriasis rubra pilaris (PRP) are striking, the microscopic diagnosis can be difficult because changes can be subtle and can overlap with other skin diseases. Suprabasal acantholysis can be seen in PRP, mimicking pemphigus vulgaris. We report a patient with PRP whose initial biopsies demonstrated subcorneal acantholysis mimicking pemiphigus foliaceus.
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