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Familial antithrombin III deficiency and Mycoplasma pneumoniae pneumonia
M D Creagh1, I F Roberts, D J Clark
1Department of Haematology, Royal Hallamshire Hospital, Sheffield.
Journal of Clinical Pathology
|October 1, 1991
Insights
A young girl
Area of Science:
- Pediatric Medicine
- Hematology
- Infectious Diseases
Background:
- Mycoplasma pneumoniae pneumonia can trigger serious complications.
- Familial thrombophilia increases the risk of blood clots.
- Antithrombin III deficiency is a known inherited bleeding disorder.
Observation:
- A 10-year-old girl experienced a large femoral vein thrombosis.
- The thrombosis occurred concurrently with Mycoplasma pneumoniae infection.
- Type I familial antithrombin III deficiency was later identified.
Findings:
- Mycoplasma pneumoniae infection can precipitate thrombosis in individuals with underlying thrombophilia.
- Type I familial antithrombin III deficiency was confirmed as a contributing factor.
Implications:
- Consider thrombosis prophylaxis in acutely ill patients with infections and known familial thrombophilia.
- Early recognition of thrombophilia is crucial in pediatric patients with unexplained thrombosis.
- Integrated management of infection and thrombophilia is essential for preventing severe thrombotic events.
Abstract:
A 10 year old girl presented with a massive femoral vein thrombosis associated with Mycoplasma pneumoniae pneumonia. Subsequently type I familial antithrombin III deficiency was diagnosed. It is suggested that prophylactic measures aimed at preventing thrombosis should be considered in acutely ill subjects with infection and familial thrombophilia.