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Updated: Jun 21, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

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Published on: February 10, 2017

The ESCHAR trial: should it change practice?

David D I Wright¹

¹BTG International Limited, London, United Kingdom. david.wright@btgplc.com

Perspectives in Vascular Surgery and Endovascular Therapy

|July 16, 2009

Summary

This summary is machine-generated.

Superficial vein surgery combined with compression did not accelerate venous leg ulcer healing. However, surgery significantly reduced ulcer recurrence compared to compression alone, making it a valuable consideration for patients.

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Area of Science:

Vascular Surgery
Dermatology
Wound Healing

Background:

Venous leg ulcers are primarily caused by venous disease, often linked to superficial vein incompetence leading to venous hypertension.
The ESCHAR trial investigated the efficacy of superficial vein surgery plus compression versus compression alone for venous leg ulcers.

Purpose of the Study:

To evaluate the impact of superficial vein surgery combined with compression on venous leg ulcer healing and recurrence rates.
To compare outcomes between patients receiving surgery plus compression and those receiving compression alone.

Main Methods:

A randomized trial involving 500 patients with chronic or recently healed venous leg ulcers.
Interventions included superficial vein surgery (saphenofemoral or saphenopopliteal procedures) with compression, or compression alone.

Main Results:

Ulcer healing rates at 24 weeks were similar between groups (65%), with no significant benefit observed for surgical intervention in promoting healing.
Superficial vein surgery was associated with a halving of ulcer recurrence rates, irrespective of deep vein incompetence.

Conclusions:

Superficial vein surgery is not recommended for accelerating the healing of venous leg ulcers.
Consideration of superficial vein surgery is advised for leg ulcer patients to decrease the likelihood of ulcer recurrence.