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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...

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Related Experiment Video

Updated: Jun 21, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Functioning and disability in bipolar disorder: an extensive review.

J Sanchez-Moreno1, A Martinez-Aran, R Tabarés-Seisdedos

  • 1Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, IDIBAPS, Barcelona, Spain.

Psychotherapy and Psychosomatics
|July 16, 2009
PubMed
Summary

Bipolar disorder significantly impairs work, family, and social life, even in remission. Residual symptoms and neurocognitive deficits are key factors contributing to this low functioning in patients.

Related Experiment Videos

Last Updated: Jun 21, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Bipolar disorder is often perceived to have a better functional outcome than schizophrenia.
  • However, evidence suggests significant functional impairment in bipolar disorder patients, even during clinical remission.
  • This highlights a need to better understand functioning and disability in this population.

Purpose of the Study:

  • To determine the degree of functioning and disability in patients with bipolar disorder.
  • To review factors potentially associated with low functioning in bipolar disorder patients.

Main Methods:

  • An extensive literature search of Medline and Pubmed databases (1980-2007) was conducted.
  • Relevant articles reporting clinically significant findings on functioning and disability were reviewed.
  • Bibliographies of retrieved articles were analyzed for further relevant publications.

Main Results:

  • Bipolar disorder is associated with significant impairments in work, family, and social life, extending beyond acute phases.
  • Subsyndromal symptoms and neurocognitive impairment are identified as major risk factors for low functioning and disability.
  • These impairments impact multiple life domains even when acute symptoms are managed.

Conclusions:

  • Pharmacological and psychological interventions can potentially improve functioning and reduce disability in bipolar disorder.
  • Interventions should target residual symptoms, comorbid conditions, and neurocognitive deficits.
  • Further research is needed to identify predictors of functioning in bipolar disorder patients.